We wilWl sooCommon types of prohormones on the market [edit] 4-androstenedione Converts to: testosterone Characteristics: Research indicates a conversion rate of about 5.9%, which means that of the amount taken orally, 5.9% is converted to testosterone. Relatively high rate of aromatization to estrogens, and consequently higher risk of side-effects such as gynecomastia brought on by excessive estrogen formation. Exhibits significant androgenic properties, which may result in side effects such as male pattern baldness, acne, and enlarged prostate.[citation needed] [edit] 4-androstenediol (4-AD) Converts to: testosterone Characteristics: Conversion rate of about 15.76%, almost triple that of androstenedione, due to utilization of a different enzymatic pathway. No direct conversion to estrogen, though some secondary aromatization does occur through metabolism. Appears to be less androgenic than its cousin, since it does not metabolize into the potent androgen dihydrotestosterone (DHT).[citation needed] [edit] 19-norandrostenedione Converts to: nortestosterone (also called nandrolone) Characteristics: Only slightly less anabolic than testosterone. Low rate of aromatization to estrogens. Low occurrence of androgenic side effects.[citation needed] [edit] 19-norandrostenediol Converts to: nortestosterone Characteristics: Same as -dione, except (as with the andros), the conversion rate is higher.[citation needed] [edit] 1-androstenediol (1-AD) Converts to: 1-testosterone, a 5-alpha reduced steroid reported to be 700% more anabolic and 200% more androgenic than testosterone; 1-testosterone is better (although rarely) described as dihydroboldenone, the 5-alpha reduced version of the veterinary steroid boldenone[citation needed] Characteristics: Very high conversion rate, because the liver serves primarily to "activate" the compound as it passes through rather than to break it down and excrete it, as is the case with other prohormones. Cannot aromatize to estrogen either directly or through any of its metabolic products. However, 1-Testosterone, being a 5-alpha reduced steroid, is highly androgenic; it is very similar to Dihydrotestosterone (DHT). Many side effects associated with excessive levels of DHT, including male pattern baldness, testicular shrinkage, benign prostate hypertrophy and acne can occur with 1-AD usage. (Journal of Organic chem. vol, 27 1962 iss.1) As with other -diols, 1-AD cannot convert directly to estrogen.[citation needed] [edit] 1,4-androstadienedione (1,4 AD) Converts to: boldenone Characteristics: High level of oral bioavailability. Low rate of aromatization to estrogens (approximately half that of testosterone). Low occurrence of androgenic side effects.[citation needed] [edit] Methyl 1-testosterone (M1-T) Characteristics: similar to testosterone except instead of a 4,5-double bond it has a 1,2-double bond. has about 20% oral bioavailability compared with less than 5% for testosterone non-aromatizing to estrogen or DHT has irritative properties making it too painful to inject, and has extremely bitter taste, making transcutaneous topical solutions the only practical human delivery method. It was commercialized this way in the United States before 2005, when it became illegal together will all other prohormones. History: 1-T was discovered in the 1950s, explored as a potential anabolic product by the pharmaceutical company G.D. Searle, but not commercialized at the time due to difficulty in delivery.[citation needed] Also considered a steroid [edit] Prohormones today A number of new Prohormones have been introduced in the past few years due to advances by supplement manufacturers. They include the following:
17b-methoxytrienosterone M-1,4ADD (17a-methyl-1,4-androstadiene-3,17diol) andrenosterone, 11-oxo-androstenedione 12-ethyl-3-methoxy-gona-diene 17b-Methoxy-Trienbolone 2-androstenol acetate These compounds all have differing characteristics, varying significantly between those that are androgenic (masculinizing) and those which have estrogenic effects when ingested in the body.[3][ n list
Chemical Names for Prohormones and Other Information
19-norandrostened Common types of prohormones on the market
4-androstenedione Converts to: testosterone Characteristics: Research indicates a conversion rate of about 5.9%, which means that of the amount taken orally, 5.9% is converted to testosterone. Relatively high rate of aromatization to estrogens, and consequently higher risk of side-effects such as gynecomastia brought on by excessive estrogen formation. Exhibits significant androgenic properties, which may result in side effects such as male pattern baldness, acne, and enlarged prostate.[citation needed]
4-androstenediol (4-AD) Converts to: testosterone Characteristics: Conversion rate of about 15.76%, almost triple that of androstenedione, due to utilization of a different enzymatic pathway. No direct conversion to estrogen, though some secondary aromatization does occur through metabolism. Appears to be less androgenic than its cousin, since it does not metabolize into the potent androgen dihydrotestosterone (DHT).[citation needed]
ione Converts to: nortestosterone (also called nandrolone) Characteristics: Only slightly less anabolic than testosterone. Low rate of aromatization to estrogens. Low occurrence of androgenic side effects.[citation needed]
19-norandrostenediol Converts to: nortestosterone Characteristics: Same as -dione, except (as with the andros), the conversion rate is higher.[citation needed]
1-androstenediol (1-AD) Converts to: 1-testosterone, a 5-alpha reduced steroid reported to be 700% more anabolic and 200% more androgenic than testosterone; 1-testosterone is better (although rarely) described as dihydroboldenone, the 5-alpha reduced version of the veterinary steroid boldenone[citation needed] Characteristics: Very high conversion rate, because the liver serves primarily to "activate" the compound as it passesthrough rather than to break it down and excrete it, as is the case with other prohormones. Cannot aromatize to estrogen either directly or through any of its metabolic products. However, 1-Testosterone, being a 5-alpha reduced steroid, is highly androgenic; it is very similar to Dihydrotestosterone (DHT). Many side effects associated with excessive levels of DHT, including male pattern baldness, testicular shrinkage, benign prostate hypertrophy and acne can occur with 1-AD usage. (Journal of Organic chem. vol, 27 1962 iss.1) As with other -diols, 1-AD cannot convert directly to estrogen.[citation needed]
1,4-androstadienedione (1,4 AD) Converts to: boldenone Characteristics: High level of oral bioavailability. Low rate of aromatization to estrogens (approximately half that of testosterone). Low occurrence of androgenic side effects.[citation needed]
Methyl 1-testosterone (M1-T) Characteristics: similar to testosterone except instead of a 4,5-double bond it has a 1,2-double bond. has about 20% oral bioavailability compared with less than 5% for testosterone non-aromatizing to estrogen or DHT has irritative properties making it too painful to inject, and has extremely bitter taste, making transcutaneous topical solutions the only practical human delivery method. Itwas commercialized this way in the United States before 2005, when it became illegal together will all other prohormones.
Prohormones today
A number of new Prohormones have been introduced in the past few years due to advances by supplement manufacturers. They include the following:
17b-methoxytrienosterone M-1,4ADD (17a-methyl-1,4-androstadiene-3,17diol) andrenosterone, 11-oxo-androstenedione 12-ethyl-3-methoxy-gona-diene 17b-Methoxy-Trienbolone 2-androstenol acetate These compounds all have differing characteristics, varying significantly between those that are androgenic (masculinizing) and those which have estrogenic effects when ingested in the body.[3][
istory: 1-T was discovered in the 1950s, explored as a potential anabolic product by the pharmaceutical company G.D. Searle, but not commercialized at the time due to difficulty in delivery.[citation needed] Also considered a steroid